Mild to moderate male pattern hair loss affects about 50% of men in the United States and Europe by age 50.

Hair loss is a common problem with many men. In fact in a US survey of single, balding men, the biggest appearance-related concern was hair loss. So if you're worried about it, you're not alone. Hair loss can begin in your teens, 20s, or 30s, and by the time you notice it, 50% of your hair may already be gone.

Scientists believe a hormone known as DHT (dihydrotestosterone) and family history are both key factors in hair loss. DHT can shrink the hair follicle until it no longer produces visible hair. In men with a family history of hair loss, DHT is believed to contribute to the progressive shrinking of hair follicles and a decrease in the number of visible hairs. In short, if you have a family history of hair loss on either side of your family, you may have an increased risk for male pattern hair loss.

Avodart is a new medicine made by GlaxoSmithKline which contains the active ingredient Dutasteride. Avodart was originally developed for treating prostate enlargement, a condition known as Benign Prostatic Hyperplasia (BPH) in men but during testing it was soon noticed that Avodart (Dutasteride) caused significant hair regrowth. Currently, it has passed Phase II of US Federal Food and Drug Administration testing for the treatment of hair loss in men.

Avodart inhibits a hormone known as DHT (dihydrotestosterone). DHT is a hormone that appears to cause hair loss (also known as MPB - Male Pattern Baldness) in most men. Avodart works by inhibiting the activities of two types of 5-alpha-reductase enzymes. These enzymes are responsible in the body for converting testosterone to dihydrotestosterone (DHT). Avodart will lower DHT levels substantially.

Both medications work in a similar way, lowering DHT levels. However, Avodart inhibits the action of two types of 5-alpha-reductase enzymes (type I and type II). Propecia (Finasteride) only inhibits one type of the enzyme (type II). Avodart (Dutasteride) is more potent, decreasing levels of DHT by about 30% more than Propecia (Finasteride).

GlaxoSmithKline, the maker of Dutasteride, has completed Phase II trials for the FDA approval of Dutasteride as a treatment for hair loss. After six months of treatment, hair counts measured in a 1 inch diameter increased by about 96 hairs with 0.5mg of Dutasteride. This is compared with an increase of only 72 hairs with the administration of 5mg Finasteride (Propecia). Results so far are very promising, however the FDA has yet to approve the medication for the treatment of hair loss.

Avodart was proved to be generally well tolerated by most. In trials, most side effects experienced were mild and generally went away while on treatment. Side effects experienced for the first six months were Impotence, decreased libido, breast tenderness and enlargement, lower volume of ejaculations. Interestingly these side effects (at a lower rate) were also experienced to a degree in the placebo group.

You should never take any medication without your doctor's approval. Consult with your doctor to see if Avodart (Dutasteride) is right for you. Please note that Avodart is for MEN ONLY. Women and children should avoid getting in contact with the capsules

Contact with the semen from a man being treated with Propecia is not a risk to the unborn child of a pregnant woman.

Yes, you can take Avodart (Dutasteride) if you and your wife are trying to conceive or if your wife is currently pregnant. However, women who are or may potentially be pregnant must not use Avodart (Dutasteride) and should not handle crushed or broken tablets of Avodart (Dutasteride). The tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets have not been broken or crushed.

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Propecia (Finasteride) works on a key cause of hair loss by significantly reducing the amount of DHT. Specifically, Propecia (Finasteride) blocks the formation of DHT in your scalp. Lowering DHT appears to inhibit the further shrinking of affected hair follicles.

Propecia (Finasteride) also helps regrow visible hair and reduces further hair loss. It is, in fact, the first and only FDA-approved pill proven to treat male pattern hair loss on the vertex (top of head) and anterior mid-scalp area (middle front of head) in men.

A 5-year clinical study studied the effectiveness of Propecia (Finasteride).

• 9 out of 10 men on Propecia (Finasteride) had visible results (either regrowth of hair, 48% [134 out of 279], or no further hair loss, 42% [117 out of 279]) vs 25% (4 out of 16) on placebo (sugar pill), according to an assessment of photographs by an independent panel of dermatologists.
• 2 out of 3 men on Propecia (Finasteride) regrew hair, as measured by hair count. All the men in the study who were not taking Propecia (Finasteride) lost hair.
• A majority of men on Propecia (Finasteride) were rated as improved by doctors: 77% (210 out of 271) vs 15% (2 out of 13) with placebo.
• A majority of men on Propecia (Finasteride) reported their bald spot getting smaller, their hair loss slowing down, and the appearance of their hair improving.
• What's more, in the first year of the study, 86% (587 out of 679) of men on Propecia (Finasteride) maintained hair or increased the number of visible hairs vs 42% (282 out of 672) on placebo.

A study showed that hair grew in thicker and/or faster. Propecia (Finasteride) grows natural hair, not just "peach fuzz." At the end of a 4-year study, there was an increase in the weight of hair samples taken from the men on Propecia (Finasteride) compared to hair samples taken from the men on a placebo (sugar pill).

You may see less hair loss in as little as 3 months. You will need to take Propecia (Finasteride) for as long as you want to grow or maintain your hair. If you stop taking Propecia (Finasteride), you will likely lose the hair you have gained within 12 months of stopping treatment.

Five years of clinical data with Propecia (Finasteride) show the sooner, the better. If you have male pattern hair loss, the sooner you get started on Propecia (Finasteride), the more hair you may have later. In fact, in the longest reported controlled study of male pattern hair loss ever conducted, men who were started on a placebo (sugar pill) and then placed on Propecia (Finasteride) 1 year later never caught up to the men who were on Propecia (Finasteride) for the full 5 years.

In the first year of the study, 86% (584 out of 679) of the men on PROPECIA maintained hair or increased the number of visible hairs vs 42% (282 out of 672) of the men on placebo.

Propecia (Finasteride) is for use by MEN ONLY and should NOT be used by women or children. Women who are or may potentially be pregnant must not use Propecia (Finasteride) and should not handle crushed or broken Propecia (Finasteride) tablets. If a woman who is pregnant comes into contact with the active ingredient in Propecia (Finasteride), a doctor should be consulted. Propecia (Finasteride) tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets are not broken or crushed.

Clinical studies showed that side effects were uncommon and did not affect most men. A small number of men had sexual side effects, with each occurring in less than 2% of men. These included less desire for sex, difficulty in achieving an erection, and a decrease in the amount of semen. These side effects went away in men who stopped taking Propecia (Finasteride) because of them. In addition, these side effects decreased to 0.3% or less by the fifth year of treatment.

In general use, the following rare side effects have been reported: allergic reactions including rash, itching, hives, and swelling of the lips and face; problems with ejaculation; breast tenderness and enlargement; and testicular pain. You should promptly report to your doctor any changes in your breasts such as lumps, pain, or nipple discharge. Tell your doctor about these or any other side effects.

Contact with the semen from a man being treated with Propecia is not a risk to the unborn child of a pregnant woman. Yes, you can take Propecia (Finasteride) if you and your wife are trying to conceive or if your wife is currently pregnant. However, women who are or may potentially be pregnant must not use PROPECIA and should not handle crushed or broken tablets of Propecia (Finasteride). However, tablets are coated and will prevent contact with the active ingredient during normal handling, provided that the tablets have not been broken or crushed.

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